Cancer Genomics Lab
Cancer is complex disease with variable presentation and outcomes thus requires multidisciplinary approach for prevention, early detection and better management. The field of oncology is gradually shifting from “one size fits all” approach towards personalize medicine based on genetic variants. The role of cancer genomics is increasing steadily for prevention, early detection and better patient’s management. Furthermore, rate of inherited cancers is higher in countries with consanguineous marriages and Pakistan is no exception. The genetic architecture varies across populations and every country retains particular cancer disposition spectrum. The state of art lab is established to promote multidisciplinary cancer research at PINUM to investigate inherited cancer dispositions and to establish diagnostic services for targeted therapies. Available Genetic Tests • Hereditary Cancer testing by NGS (27 Gene Panel) • BRCA1/2 testing by NGS • BRCA1 common mutation testing • BRCA1/2 carrier testing • JAK2 Mutation • BCR-ABL Qualitative (p210/p190) • BCR-ABL Quantitative p210 (IS) • ABL1 Kinase Domain Mutation • TP53 Mutations by NGS Available services to academia In addition to the above mentioned clinical tests, following services will be available to academia and research institutes at economical rates. • Fragment Analysis by Capillary Electrophoresis • DNA Sequencing Unidirectional (without Cleansing) • DNA Sequencing Bidirectional (without Cleansing) • DNA Sequencing Unidirectional + Cleansing • DNA Sequencing Bidirectional +Cleansing Lab Technical Team: The Lab has the following personals available to perform the routine lab work. • Dr. Rubina Tabassum,PhD, Section Head • Dr. Hamid Shabbir,PhD (Germany) • Ms Nabila Aman, BS (Hons) Training We offer short apprenticeship to graduate and post graduate students of universities and medical colleges in the field of Genomics. Research • Our focus is to elucidate genetic spectrum of hereditary breast and ovarian cancer (HBOC), hereditary non polyposis colorectal cancer (HNPCC) and familial medullary thyroid carcinoma (FMTC) in Pakistani population. • In addition we are interest to develop non-invasive urinary biomarkers to predict low risk/benign prostate cancer to circumvent unnecessary biopsies.
Experts
